Scientific Articles

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Science Explains 10 Things That Cause an Overactive Bladder – Click Here

Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence – Click Here

Transcutaneous tibial nerve stimulation to treat urgency urinary incontinence in older women – Click Here

Nerve growth factor combined with vascular endothelial growth factor enhances regeneration of bladder acellular matrix graft in spinal cord injury-induced neurogenic rat bladder – Click Here

Neurogenic Bladder Repair Using Autologous Mesenchymal Stem Cells – Click Here

Combined injection of three different lineages of early-differentiating human amniotic fluid-derived cells restores urethral sphincter function in urinary incontinence – Click Here

Electroacupuncture for stress-related urinary incontinence in elderly women: data analysis from two randomised controlled studies – Click Here

Natural killer cells, T cells, and neutrophils are recruited upon SDF-1 secretion – Click Here

Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle – Click Here

Electrical pulse stimulation of skeletal myoblasts cell cultures with simulated action potentials – Click Here

New USC clinical trial examines a potential noninvasive solution for overactive bladder

Researchers will use a technique known as Transcutaneous Electrical Spinal Cord Neuromodulation (TESCoN), a noninvasive therapy that delivers low-intensity electric impulses

In this double-blinded, sham-controlled trial, half the participants will receive two one-hour sessions of TESCoN per week over 12 weeks. The stimulation will be applied via electrodes attached to a device that emits low-intensity impulses through adhesive pads placed on the patient’s back. The other half of the participants will receive a placebo, or sham stimulation over course of the trial.

New clinical trial examines a potential noninvasive solution for overactive bladder

Neuroscientists restore significant bladder control to 5 men with spinal cord injuries
In UCLA study, magnetic stimulation of lower spine eliminates need for catheter for up to 4 weeks

Female Bladder Leakage: Solutions to Get Control‎ | UCLA

Improving Bladder Function in SCI by Neuromodulation

Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial. – Click Here

The bladder can regenerate like nobody’s business and now we know …


Jul 31, 2018 – When damaged by infection or injury, the organ can mend itself quickly, calling upon specialized cells in its lining to repair tissue and restore a barrier against harmful materials concentrated in urine. … It can contribute cells that migrate to the bladder, adopt bladder-like …
Yang B, Li M, Lei H, Xu Y, Li H, Gao Z, Guan R, Xin Z.
Urology. 2018 Sep 28. pii: S0090-4295(18)31052-5. doi: 10.1016/j.urology.2018.09.020. [Epub ahead of print]
 2018 Sep 28. pii: S0090-4295(18)31052-5. doi: 10.1016/j.urology.2018.09.020. [Epub ahead of print]

Low Intensity Pulsed Ultrasound Influences the Myogenic Differentiation of Muscle Satellite Cells in a Stress Urinary Incontinence Rat Model.

Yang B1, Li M1, Lei H1, Xu Y2, Li H1, Gao Z1, Guan R1, Xin Z3.



To investigate the therapeutic effect of low intensity pulsed ultrasound (LIPUS) in a stress urinary incontinence (SUI) rat model and its influence on myogenic satellite cells.


Fifty Sprague-Dawley rats underwent vaginal distension and bilateral ovariectomy mimicking partum injury and menopause to construct SUI models, which were further randomized into 100 mW/cm2 LIPUS, 200 mW/cm2 LIPUS, 300 mW/cm2 LIPUS, and none-treatment control subgroups with 10 rats per subgroup. Ten rats served as mock operation control. Leak point pressure and bladdercapacity were recorded 1 week after LIPUS treatment. Immunofluorescence staining and Western blot were performed to examine histological changes, myodifferentiation, and signaling pathway.


Here,we found the leak point pressure and bladder capacity were restored in 200 mW/cm2 LIPUS and 300 mW/cm2 LIPUS groups, but not in 100 mW/cm2 LIPUS group. More robust striated muscle regeneration was observed in 200 mW/cm2 LIPUS group comparing with the SUI none-treatment group. Moreover, we found LIPUS activated the myodifferentiation of muscle satellite cells, which is correlated to p38 phosphorylation level.


LIPUS restored the leak point pressure and bladder capacity, and activated satellite cell myodifferentiation in SUI rat model.

Bioengineering Approaches for Bladder Regeneration – NCBI – NIH
by Á Serrano-Aroca – ‎2018

Jun 17, 2018 – The purpose of this work is to review the state of the art of the current bioengineering advances and obstacles reported in bladder regeneration.

The Current Use of Stem Cells in Bladder Tissue Regeneration and …
by YY Chan – ‎2017 – ‎Cited by 9 – ‎Related articles

Jan 6, 2017 – The use of intestinal tissue, however, subjects patients to metabolic abnormalities , bladder stones, and other long-term sequelae, raising the …

Bladder regeneration in a canine model using a bladder acellular …
by C Shi – ‎2017 – ‎Cited by 3 – ‎Related articles

Biomater Sci. 2017 Nov 21;5(12):2427-2436. doi: 10.1039/c7b


The Current Use of Stem Cells in Bladder Tissue Regeneration and …
by YY Chan – ‎2017 – ‎Cited by 9 – ‎Related articles

Jan 6, 2017 – SIS has been shown to foster bladder regeneration without ex vivo cell … Current studies utilizing stem cells in various capacities for bladder …

Bioengineering Approaches for Bladder Regeneration – NCBI – NIH
by Á Serrano-Aroca – ‎2018

Jun 17, 2018 – Tissue Engineering for Urinary Bladder Regeneration …. bioreactor to study the effect of a cyclic uniaxial strain on urinary bladder cells [48].

Bladder regeneration: great potential but challenges remain …
by WA Farhat – ‎2011 – ‎Cited by 6 – ‎Related articles

Bladder regeneration: great potential but challenges remain … The two areas that have been thoroughly studied in the tissue engineering field are biomaterial …

The promotion of functional urinary bladder regeneration using anti …
by MI Bury – ‎2014 – ‎Cited by 22 – ‎Related articles

Within the context of this proof-of-concept study, we have attempted to specifically …. Blood vessel quantification in areas of bladder tissue regeneration.


Neurogenic Bladder Repair Using Autologous Mesenchymal Stem Cells


by PV Mahajan – ‎2016 – ‎Cited by 1 – ‎Related articles

Aug 8, 2016 – Neurogenic bladder is a term applied to a malfunctioning urinary bladder … repair as these techniques do not result in neuronal regeneration.

Stem Cell Therapy in Bladder Dysfunction: Where Are We? And …


by JH Kim – ‎2013 – ‎Cited by 32 – ‎Related articles

Aug 7, 2013 – To date, stem cell therapy for the bladder has been conducted mainly … Bladder regeneration by differentiation has been frequently reported in ..


Transurethral Myoblast Injection for Urinary Incontinence in Children …


Mar 3, 2014 – Considering the limited capacity of the rhabdosphincter for regeneration, the idea of urethral sphincter repair in patients with bladder extrophy …

Regenerative Therapy for Stress Urinary Incontinence – ScienceDirect
by R Jankowski – ‎2008 – ‎Cited by 5 – ‎Related articles

Regenerative Therapy for Stress Urinary Incontinence …. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the …


Understanding the role of mesenchymal stem cells in urinary bladder …


5 hours ago – The data demonstrate that ADSCs support regeneration of large defects of the urinary bladder wall but the process is incomplete in the central …

Using hair-follicle stem cells for urinary bladder-wall regeneration ……
by T Drewa – ‎2008 – ‎Cited by 30 – ‎Related articles

The present paper focuses on the idea of harvesting potentially multipotent stem cells out of hair follicles in order to use them for regeneration of the urinary …


Electrical Stimulation for Urinary Incontinence & Overactive Bladder › Incontinence & Overactive Bladder › Reference


Feb 13, 2018 – It uses a mild electric current to treat your overactive bladder (OAB) and ease your strong urge to pee. Electrical stimulation may give you better control over the muscles in your bladder, a sac-shaped organ that holds your urine.

You visited this page on 11/20/18.

Non-invasive electrical stimulation for overactive bladder in adults ……/INCONT_non-invasive-electrical-stimulation-overactive-…


Dec 9, 2016 – Treatment for OAB includes pelvic floor muscle training, drug therapy and electrical stimulation. Non-invasive electrical stimulation works by passing an electrical current through the bladder muscles, via a vaginal or anal probe, or through a fine needle inserted into the tibial nerve around the ankle.

Using Electrical Stimulation for Urinary Incontinence – NCBI – NIH


by JY Lee – ‎2002 – ‎Cited by 2 – ‎Related articles

Jump to A Norwegian National Cohort of 3198 Women Treated with Home … – ES for urinaryincontinence appears to be covered … for reimbursable ES therapy .

How Microcurrent Therapy Tightens Your Skin and Heals Injuries…


Jun 26, 2018 – Microcurrent therapy sends low-level electrical currents into your skin that are nearly identical to the body’s own natural electrical frequencies, …
Gasanz C, Raventós C, Temprana-Salvador J, Esteves M, Fonseca C, de Torres I, Morote J.
Cent European J Urol. 2018;71(3):353-359. doi: 10.5173/ceju.2018.1735. Epub 2018 Aug 13.

Free PMC Article

 2018;71(3):353-359. doi: 10.5173/ceju.2018.1735. Epub 2018 Aug 13.

Use of an acellular collagen-elastin matrix to support bladder regeneration in a porcine model of peritoneocystoplasty.



Bladder reconstruction without using the intestine remains a challenge to this day despite the development of new biomaterials and cell cultures. Human bladder engineering is merely anecdotic, and mostly in vitro and animal studies have been conducted.


In our study using a porcine model, we performed a bladder augmentation using an autologous parietal peritoneum graft (peritoneocystoplasty) and determined whether the attachment of an acellular collagen-elastin matrix (Group 1) or lack of (Group 2) had better histologic and functional results. Thus far, peritoneocystoplasty has rarely been performed or combined with a biomaterial.


After 6 weeks, we observed different degrees of retraction of the new bladder wall in both groups, although the retraction was lower and the histological analysis showed more signs of regeneration (neoangiogenesis and less fibrosis) in Group 1 than when compared with Group 2. No transitional cells were found in the new bladder wall in any of the groups, and no differences were observed in the functional test results.


Performing a peritoneocystoplasty is an easy and safe procedure. The data supports the benefit of an acellular collagen-elastin matrix to reinforce bladder regeneration. However, in our study we observed too much retraction of the new wall and the histologic results were not acceptable to consider it an appropriate cystoplasty technique.


acellular matrix; biomaterial; bladder regeneration; peritoneocystoplasty; tissue engineering
Cao N, Song L, Liu W, Fan S, Jiang D, Mu J, Gu B, Xu Y, Zhang Y, Huang J.
Biomed Mater. 2018 Oct 25;14(1):015002. doi: 10.1088/1748-605X/aae5e2.